Hypoxia Selects Bortezomib-Resistant Stem Cells of Chronic Myeloid Leukemia
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چکیده
منابع مشابه
Hypoxia Selects Bortezomib-Resistant Stem Cells of Chronic Myeloid Leukemia
We previously demonstrated that severe hypoxia inhibits growth of Chronic Myeloid Leukemia (CML) cells and selects stem cells where BCR/Abl(protein) is suppressed, although mRNA is not, so that hypoxia-selected stem cells, while remaining leukemic, are independent of BCR/Abl signaling and thereby refractory to Imatinib-mesylate. The main target of this study was to address the effects of the pr...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0017008